Today, ketamine is a safe, effective analgesic and a clinically proven treatment for persistent depression. Initially synthesized in 1962 by a chemistry professor and consultant for Parke-Davis, ketamine ultimately replaced phencyclidine (PCP) as the preferred anesthetic for individuals undergoing major operations. In 1970, the Food and Drug Administration (FDA) approved ketamine as an anesthetic so that Vietnam War soldiers injured on the battlefield could get rapid relief from pain.